Decellularization of Trachea With Combined Techniques for Tissue-Engineered Trachea Transplantation
نویسندگان
چکیده
منابع مشابه
Tissue-engineered trachea for airway reconstruction.
OBJECTIVES/HYPOTHESIS Scaffold-free cartilage has been used to engineer biocompatible and mechanically stable neotracheas in vivo. The purpose of this animal study was to determine if neotracheal constructs, implanted paratracheally, could successfully be used for segmental tracheal reconstruction. STUDY DESIGN Animal study. METHODS Culture-expanded auricular rabbit chondrocytes were used t...
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Objectives: Surgical treatment of segment tracheal reconstruction longer than 6 cm needs trachea substitutes, tissue engineering can provide alternatives for tracheal reconstruction. Constructs with blood supply are preferred for tracheal replacement. Here we describe an approach for engineering of vascularized trachea with ectopic pedicled muscle flap. Methods: Poly (L-lactic-co-glycolic acid)...
متن کاملTissue-engineered trachea: History, problems and the future.
This review tries to summarize the efforts over the past 20 years to construct a tissue-engineered trachea. After illustrating the main technical bottlenecks faced nowadays, we discuss what might be the solutions to these bottlenecks. You may find out why the focus in this research field shifts dramatically from the construction of a tubular cartilage tissue to reepithelialization and revascula...
متن کاملTissue engineered cartilage generated from human trachea using DegraPol scaffold.
OBJECTIVE To date numerous attempts have been undertaken to conquer the challenging problem of reconstructing long segmental tracheal defects, as yet without lasting success. Recently, employing concepts of tissue engineering in animals, cartilage-like constructs were transplanted in vivo. However, both the feasibility of fabricating tracheal replacements and the use of human tracheal chondrocy...
متن کاملPreliminary experiences in trachea scaffold tissue engineering with segmental organ decellularization.
OBJECTIVES/HYPOTHESIS Ideal methods for reconstructing the tracheal structure and restoring tracheal function following damage to the trachea or removal of the trachea have not been developed. The purpose of this study is to evaluate the feasibility of using a whole segment decellularized tracheal scaffold to reconstruct the trachea. STUDY DESIGN Prospective experimental design. SETTING In ...
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ژورنال
عنوان ژورنال: Clinical and Experimental Otorhinolaryngology
سال: 2019
ISSN: 1976-8710,2005-0720
DOI: 10.21053/ceo.2018.00486